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Systematic review and meta-analysis of COMT, DAT, DBH, DDC, DRD1-5, MAOA, MAOB, TH, VMAT1, and VMAT2

NakayamaHChenXBainesCPKlevitskyRZhangXZhangHet al

The two-hit vascular hypothesis of Alzheimer's disease proposes that BBB dysfunction allows neurotoxins to enter the brain parenchyma, which in turn leads to neuroinflammation[43]