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Nonetheless, whether the specific mechanism of this is related to the transdifferentiation of VSMCs to a bone-like phenotype, loss in SMC lineage markers, enhanced pro-calcific microRNAs, increased intracellular calcium level, apoptosis, or aberrant DNA damage response (DDR) requires further investigation

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In fact, DiNicolantonio et al.[15] found a 40% reduction in angina symptoms and a 65% decrease in dangerous heart rhythms, making it a valuable tool for improving quality of life in people with heart conditions

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