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However, due to the insufficiency of clinical evidence, it cannot be used as a first-line treatment drug at present

The chemistry is sound

Avoid Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25C

they are of 3rd or 4th choice after failure of response to SSRIs or SNRIs) because MAOIs have more significant side effects (including orthostatic hypotension), food restrictions, drug-drug interactions, and greater risk for harm at high doses

In addition, Caveolin-1 (Cav-1), a 21-kDa integral plasma membrane protein is a well-known negative regulator of eNOS activity in vascular endothelial cells 17,18,19,20,21,22