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When tested in normal human volunteers, it was found to exert sedative properties, but when tested in ~500 patients with various psychiatric disorders, only those with endogenous depression exhibited a remarkable improvement of clinical symptoms after 1-6 weeks of daily treatment

Proc Natl Acad Sci 68:29822985 Veeravalli K, Boyd D, Iverson BL, Beckwith J, Georgiou G (2011) Laboratory evolution of glutathione biosynthesis reveals natural compensatory pathways

Table 4 Studies on natural products showed a beneficial effect on gut microbiota, liver, and hypothalamus

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doi: 10.1016/j.ccr.2010.05.023 101 HsiehACCostaMZolloODavisCFeldmanMETestaJRet al