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Obstet Gynecol 98(2):319324 Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding

Using artificial engineered substrates that mimic the chemical, mechanical, and physical properties of highly organized ECM fibers, and so controlling their spatial density, it was shown in a recent study that the fiber density variation can be sensed by fibroblasts, and interestingly different cell types exhibit different sensitivities along a density gradient depending on their cortical stiffness (Kim et al., 2012)

Furst, J

Cancer Cell 23 , 811825 (2013)

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