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Piperlongumine Piperlongumine (PL) is an alkaloid isolated from Piper species, commonly used in traditional medicine in particular in Asia and Latin America that in recent years has been extensively studied because of its anti-cancer potential, being able to inhibit proliferation in several cancer cell lines 107

According to our structure, the octanoyl group is located at cavity II but not cavity I, which is different from the previous modeling studies 17,18,19