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doi: 10.1080/01926230290166724 54 HalliwellB

Palliative Medicine

Research Use Only Not for Human or Animal Consumption

Silent Information Regulator 1 (SIRT1), a member of the HDAC family of HDACs, slows the progression of As by inhibiting macrophage LOX-1 gene expression and decreasing the phagocytosis of oxidized low-density lipoprotein by macrophages, thereby leading to a reduction in subendothelial lipid deposition (17)