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It is known to provide a physiologically acceptable electrical current(0.1-1.0 mA/cm 2 ) using an electrode of the same polarity to drive charged permeants across the SC through its potential gradient [249, 250]

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Carrier screening is typically performed using complete blood count and hemoglobin electrophoresis or HPLC in individuals from at-risk populations or during premarital or preconception counseling

Complementary studies have revealed that pharmacological inhibition of TrxR induces ferroptosis in malignant cells, suggesting its therapeutic potential in cancer treatment (85,86)