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Yet, despite its relevance, the relationship of betaine and choline to homocysteine metabolism has been only lightly investigated in humans, essentially because the choline content of foods could not be accurately measured until fairly recently

Changes in brain membrane phospholipid and high-energy phosphate metabolism precede dementia Neurobiol Aging 1995

10.1016/j.mam.2011.10.008 54 Jackson-HayesL.SongS.LavrentyevE

As a dietary supplement, take 30-60 minutes prior to training with approximately 120-180ml of water

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Biochimica et Biophysica Acta - Molecular Cell Research, 1863(10), 24222435 Garolla, A., Maiorino, M., Roverato, A., Roveri, A., Ursini, F., & Foresta, C