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Description

Although the degree of inflammation in OA is generally lower than in rheumatoid arthritis, synovial tissue can still exhibit marked hyperplasia and inflammatory cell infiltration (1)

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Dysregulation or inappropriate activation of these signaling pathways can occur due to genetic mutations, infections, or other triggers, leading to an uncontrolled and amplified cytokine response

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This accumulation causes oxidative stress-induced bacterial damage and inhibits bacterial adhesion to RAW264.7 cells

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While caspases-4, -5 and murine caspase-11 are all capable of directly binding to LPS, differences in their binding capabilities to alternative LPS forms exist and the route of LPS internalisation may also influence their activation, as demonstrated by the selective activation of caspase-5 by OMVs from P

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This allows ALA to penetrate all parts of the cell, including the lipid membranes of the mitochondria, and cross the blood-brain barrier to alleviate neuroinflammation

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