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NNC0165-1875 has recently completed a phase 2 trial in combination with semaglutide 2.4 mg once weekly (NCT04969939), but results are not currently available

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These preliminary results open fascinating research avenues, although they are still far from clinical application

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Adverse reactions after discontinuation of serotonergic antidepressants, particularly after abrupt discontinuation, include: nausea, sweating, dysphoric mood, irritability, agitation, dizziness, sensory disturbances (e.g., paresthesia, such as electric shock sensations), tremor, anxiety, confusion, headache, lethargy, emotional lability, insomnia, hypomania, tinnitus, and seizures