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Researchers monitoring GI adverse events should collect data on meal patterns to differentiate compound-related GI effects from dietary confounders, particularly during the first 812 weeks of dose escalation when GI adverse events are most frequent

The proteins were treated with rTEV protease to remove the hexahistidine-tags and dialyzed against 50 mM potassium phosphate (pH 6.6) as the final step before NMR

It has a half-life of approximately six days, which supports once-weekly subcutaneous injection

& Ekholm, R

The results showed that ERK, JNK and P38 were all activated after MIRI (Figures 7A, B), among them, Sat1 inhibition only significantly suppressed the activation of MAPK/ERK, but Sat1 over-expression did not significantly promote the activation of MAPK/ERK (Figure 7B)