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G6PD catalyzes the rate-limiting step in the pentose phosphate pathway, which provides nucleotide precursors for DNA replication as well as cytosolic reducing equivalents of the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH)

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2 and Supplementary Table 3) fulfilled all these criteria and included 1) HIF1A transcription factor network (pink), 2) hypoxic and oxygen hemostasis regulation of HIF1A (black), 3) Vascular Endothelial Growth Factor (VEGF) hypoxia and angiogenesis (blue), 4) HIF2A transcription factor network (green), 5) signaling by Transforming Growth Factor- (TGFB) receptor complex (brown), 6) signaling by Platelet Derived Growth Factor (PDGF, yellow), and 7) hypoxia response by HIF activation pathways (orange)

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Tokyo, Department of Environmental Health, Office of Health Studies, pp