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Br J Clin Pharmacol 2025 demonstrates that co-infusing a GLP-1 agonist with glucagon produces a perfectly additive HR response (+4 bpm + +4 bpm = +7 bpm at 60 min in n=12 lean males), confirming that glucagon drives chronotropy via a parallel pathway independent of GLP-1R cross-reactivity

Non-injectable (topical) formulations are Category 1 and eligible for compounding

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DOI: 10.3389/fphys.2022.834597, Grndemann, D., Hartmann, L., and Flgel, S