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The development of cell and animal models pertinent to the disease allows for the verification of the efficacy of the target and the impact of drug interventions

G6PDi-1 and DPI assays Experiments involving inhibition of glucose 6-phosphate dehydrogenase (G6PDH) were performed on the PerkinElmer Operetta CLS

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and Iredale, J

Toprak, C

GSH and necroptosis Necroptosis is a regulated form of necrotic cell death characterized by activation of RIPK3 and mixed lineage kinase domain-like pseudokinase (MLKL), with receptor-interacting serine/threonine kinase 1 (RIPK1) participating in many, but not all, necroptotic contexts