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When System Xc function becomes impaired, cells cannot import cystine efficiently, leading to glutamate accumulation, GSH depletion, and decreased GPX4 activity

Neurochem Res 37(8):16601669

Interestingly, direct fibroblast proliferation as measured by cell assay was not significantly affected, suggesting the mechanism is more nuanced than simple cell replication

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Physical activity in ovarian cancer survivors: associations with fatigue, sleep, and psychosocial functioning

Draw the water into a syringe, add it slowly down the inside wall of the vial (do not spray directly onto the powder), and let it dissolve on its own without shaking