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58 Complement components such as C3, C4c, C5, and C7 are upregulated in glomeruli, 63,64,65,66,67 activating both the classical and alternative complement pathways and generating anaphylatoxins (C3a and C5a)

Additionally, longitudinal studies examining the immediate, intermediate and long-term effects of elevated Mn exposure on children and adults are needed to identify age- and sex-specific susceptibilities, and potential biological, psychological and cognitive biomarkers