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Normal erythrocyte catabolism 90% extravascular hemolysis Spleen, liver, bone marrow, lymph nodes Globin + Heme Iron to transferrin, globin to amino acids (pool) Heme + Heme oxygenase: Biliverdin + CO2 Biliverdin is reduced to unconjugated bilirubin that binds to albumin and is transported to the liver In the liver it dissociates from albumin and is conjugated with glucuronic acid (conjugated bilirubin) Conjugated bilirubin: direct, water soluble Unconjugated bilirubin: indirect, insoluble in water, reacts with the addition of alcohol

Physical Symptoms: Fatigue, Weakness, and Balance Issues Vitamin B12 is important for making red blood cells and keeping our nervous system healthy

Although reducing saturated fat is commonly recommended for lowering ApoB and LDL-C levels, it does not meaningfully improve insulin resistance

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Contact your healthcare provider if you experience unusual or severe gastrointestinal symptoms beyond the typical side effects associated with semaglutide