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Two hours at 95 degrees might cause more damage than two full days at 72 degrees

It does so by phosphorylating cofilin, which leads to its inactivation [87], and this helps to stabilize the actin cytoskeleton

The term NNMT inhibitors as used herein refers small molecule chemical entities that inhibit the enzymatic activity of NNMT, and includes the compounds of Formula I and Formula IA as well as compounds in Tables 1-3