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Major Criteria Family history of vEDS with a documented causative variant in COL3A1 Arterial rupture at a young age Spontaneous sigmoid colon perforation in the absence of known diverticular disease or other bowel pathology Uterine rupture during the third trimester in the absence of previous C-section and/or severe peripartum perineum tears Carotid-cavernous sinus fistula (CCSF) formation in the absence of trauma Minor Criteria Bruising unrelated to identified trauma and/or in unusual sites such as the cheeks and back Thin, translucent skin with increased venous visibility Characteristic facial appearance Spontaneous pneumothorax Acrogeria Talipes equinovarus Congenital hip dislocation Hypermobility of small joints Tendon and muscle rupture Keratoconus Gingival recession and gingival fragility Early-onset varicose veins (under age 30 and starting before pregnancy if female) If a person meets the diagnostic criteria for aEDS, genetic testing should be done to confirm the diagnosis

Vitamin D and new insights into pathophysiology of type 2 diabetes

For example, cholesterol suppresses the activity of Kir1.1, Kir2.1, Kir4.1, GIRK1 (with the pore mutation F137S), and Kir6.236 (the C-terminal truncation mutant of Kir6.2) (Rosenhouse-Dantsker et al., 2010)

Caspase-9 is activated in a cytochrome C-independent manner early during tnf-induced apoptosis in murine cells

The optimal time between administration of Zostavax and vaccination with Shingrix has not been established

Key 2026 Changes Affecting Pain Management Prior Authorization in Pain Management Pain management procedures have some of the highest prior authorization (PA) denial rates of any specialty