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While the alternative of conducting these experiments on pancreata harvested from THR-123-treated mice would theoretically enable the analysis of time points significantly more extended than those afforded by the limited functional lifespan of slices in vitro, the dissociation of viable cells (especially acinar) from whole pancreatic tissue remains a major technical hurdle in the field 28

Recently, significant efforts have been made to search for the tyrosinase inhibitors with copper chelator ability as whitening and anti-hyperpigment agents 13,14,15,16,17,18 and several tyrosinase inhibitors have also been used as depigmentation ingredients of medical products 19,20,21,22

vulgaris at a dose of 100 mg/kg per day for four weeks had their serum lipid profiles normalized, their paraoxonase-1 activity significantly increased and their levels of malondialdehyde, NO and tumor necrosis factor- decreased

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Decrease in cytosolic cytochrome c rate lead to inhibition of lipid peroxidation measured as MDA liver tissue content

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