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In controlled laboratory research models, IGF-1 LR3 binds to the insulin-like growth factor-1 receptor (IGF-1R), initiating downstream signaling cascades commonly associated with PI3K/Akt and MAPK/ERK pathway activation under defined experimental conditions

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Additionally, breast milk from breastfeeding mothers, such as those in the studies by Chuisseu et al

Lolicato et al., 2020

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