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In VaD, an insufficient oxygen supply to the brain, reduced blood flow, and decreased intracellular oxygen partial pressure result in mitochondrial oxidative phosphorylation dysfunction, inhibition of protein synthesis, insufficient ATP production, and energy depletion, ultimately leading to sodium-potassium pump failure, calcium overloading, and disturbances in cytosolic ions (e.g., Ca 2+ , Na + , H + , ROS), which subsequently increase