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Overall, Spurdle et al

Nature 420:42

Both American and European guidelines recommend intravenous (i.v.) iron therapy to improve symptoms and QoL in patients with HF and a reduced left ventricular ejection fraction (LVEF) (HFrEF) and iron deficiency 5,6 , but uncertainty persists about the effects of i.v

The release of cytochrome c is controlled via the modulation of mitochondrial membrane permeabilization by the Bcl-2 protein family (Bcl-2, Bax, Bak, and Bcl-xL)