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These results directly confirm that excessive NNMT activation suppresses NAD+ synthesis and impairs energy metabolism, while NNMT inhibition effectively reverses this process, establishing NNMT as a negative regulator of energy metabolism

ClinicalTrials.gov lists 3 ongoing or completed trials (accessed February 12, 2026): NCT05239615 (topical for photoaging, Phase II, completed 2024, no results posted) [12]

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