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doi: 10.1177/15459683211046257 294 DantzerRHeijnenCJKavelaarsALayeSCapuronL

In addition to a decrease in peripheral levels of LAC, LAC levels are decreased by 4060% in the hippocampus and prefrontal cortex of rodents with depressive-like behaviors, including the Flinders Sensitive Line (FSL) rats [30]

Alfthan, G., Eurola, M., Ekholm, P., Venlinen, E.-R., Root, T., Korkalainen, K., Hartikainen, H., Salminen, P., Hietaniemi, V., Aspila, P., Aro, A., Group, S

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This microbial imbalance alters key metabolic pathways and elevates lipopolysaccharide production, leading to gut dysbiosis that adversely impacts renal function