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Then, we investigated whether DRD2 activation upregulates Nrf2 targets in primary astrocytes

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Oxidative stress and low-grade inflammation in polycystic ovary syndrome: controversies and new insights

In a pentylenetetrazole-induced convulsion model in mice, topiramate pretreatment decreased GSH levels and increased MDA levels, suggesting that TPM negatively regulates oxidative stress (Agarwal et al., 2011)