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For example, a randomized controlled trial in 2014 involving about 370 patients with osteoarthritis in the knee found that curcumin was just as effective as ibuprofen for reducing inflammation, swelling, and pain but with far fewer gastrointestinal side effects

glutathione synthesis genes in oxidative stress and detoxification subsystems, significantly increased, revealing the surviving bacteria may have higher chlorine resistance

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Nevertheless, not all isolates demonstrated augmented sensitivity at these particular concentrations