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Mitochondrial-derived reactive oxygen species and oxidized mtDNA are potent activators of the NLRP3 inflammasome, driving maturation of IL-1 and IL-18, which in turn enhance Th1 and Th17 responses essential for protection against Candida albicans and Aspergillus fumigatus (Qin et al., 2023)

Psychological comorbidities, including anxiety and depression, further amplify airway inflammation through brain-lung cross-talk, contributing to neuronal inflammation and asthma exacerbations

10.1038/s41467-022-32188-1 195 QinS.TangX.ChenY.ChenK.FanN.XiaoW.et al (2022)

It is estimated that only about 66% of people who are prescribed CPAP are properly adherent, which has remained largely unchanged over the past two decades

This speculation was further underlined by higher number of cells in sub G0/G1 population in HM fed animals as subG0/G1 cell population was more likely to undergo apoptosis 1

Turrens JF (2003) Mitochondrial formation of reactive oxygen species