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Folate's support of methylation creates another important hormone connection

Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking

In other words, dosing guidelines should aim to, as closely as possible, mimic the endogenous action and amplitude of luteinizing hormone stimulation, with care taken to avoid both under-stimulating or over-stimulating in comparison to endogenous luteinizing hormone levels

This makes it one of the very few injectable veterinary products that can be safely administered to dairy cows, milking ewes, and laying hens without any requirement to discard milk, hold back slaughter, or withdraw eggs from sale

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