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It takes getting into the guts of the situation and digging around and testing to discover the actual problem

Matsuura et al., 2004

At predetermined time points (2, 6, 12, and 24 h post-administration), the mice were euthanized, and the residual gel on the skin surface at the application site was removed by washing with PBS

Step 4: Isomerization of Ribulose-5-Phosphate to Ribose-5-Phosphate Ribulose-5-Phosphate is isomerized into Ribose-5-Phosphate by the enzyme Phosphopentose isomerase