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dose released is approximately 65 mcg/day Leuprolide: intramuscular injection (weight-based dosing)

Anti-TNF- mAb TNF- is a crucial inflammatory cytokine involved in mediating inflammation in UC patients

Bruck R, Aeed H, Shirin H, Matas Z, Zaidel L, Avni Y, et al

For 53BP1 staining, coverslips were washed with ice-cold PBS, fixed with 4% (v/v) formaldehyde in PBS for 15 min in the dark at RT, and then permeabilized with 0.1% (v/v) Triton X-100 for 10 min at RT

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Disruptions in these metabolic pathways, whether due to genetic mutations, hepatic dysfunction, or altered bile composition, lead to bilirubin supersaturation in bile, a key factor in gallstone pathogenesis