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The extracellular effects include binding to neuronal GABA A and glycine receptors, with subsequent cellular hyperpolarization, and attenuation of N -methyl-D-aspartic acid (NMDA)-mediated glutamate excitotoxicity

64 3351 (Elsevier, 2012)

It is noteworthy that Pt-induced ROS production impairs antioxidant enzymes [e.g., superoxide dismutase (SOD) and catalase (CAT)] to trigger oxidative stress (Khasabova et al., 2019), which participates in the onset and progression of both acute and chronic PIPN