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Activation of JNK leads to the production of pro-inflammatory cytokines and a shift in macrophage phenotype

During ageing, mtDNA, Tfam, ROS, ATP, cardiolipin, and N-formyl peptide can be released as DAMPs and are recognized by pattern recognition receptors upon mitochondrial stress or compromise, leading to the activation of MiDAS and SASP

Lack of Akt activation in these cells suggests that a lack of pro-survival pathways may contribute to the increased rates of cell death and apoptosis in GPx-1-deficient cells

The combination stability assay of PBA-COS conjugate at different time points

M., Heras, S

May 25 2021;doi:10.1007/s42000-021-00289-z Gadalla MA, Norman RJ, Tay CT, et al