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de Luca C, Olefsky JM

doi: 10.1182/blood-2004-10-4094 17 FrascaLFedeleGDeaglioSCapuanoCPalazzoRVaisittiTet al

however, this does not require phosphorylation of PDE3B on S273 by AKT2 (117)

Semaglutide (the GLP-1 half of CagriSema) and tirzepatide both agonize it, which is why both suppress appetite, slow gastric emptying, and improve glycemic measures