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Crucially, the ROS generated during GSH degradation by CHAC1 may also cause further TP53 mutations, creating a vicious self-reinforcing cycle: CHAC1 activity promotes the very TP53 mutations that allow the tumor to exploit CHAC1s harmful effect for growth

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The cuprum grids were observed under a transmission electron microscope (TEM

doi: 10.1038/s41380-025-03044-7, 13

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