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This additional pathway is suggested to be secondary and found in tissues with lower cytochrome P450 activity, such as kidneys [9,40]

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5 PHARMACOLOGY AND DOSING The recommended maximum total daily dose is 3900 milligrams in adults using 325-milligram acetaminophen (regular strength) and 3000 milligrams when using the 500-milligram acetaminophen (extra strength) preparation