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Animals were kept unattended for 3 days before the experiment for familiarization

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Nutritional support: Proper nutrition, particularly adequate intake of B vitamins and other nutrients involved in the cycle, is crucial for maintaining healthy methylation processes

Although beneficial in tumor cells, GPX4 inhibition can also trigger ferroptosis-induced death of immune cells in the tumor microenvironment leading to ineffective antitumor response

Although the dynamics of mtDNA methylation during embryogenesis are not well understood, associations with aging [31], environmental exposure [32], and disease [33], suggest the presence of active methylation turnover