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SLC7A11 transcript levels were also decreased with both ATF4 knockdown and rapamycin in the PTEN-deficient cancer cell lines LNCaP and PC3, although SLC7A11 expression was relatively more resistant to rapamycin in PC3 cells (Figure 6figure supplement 6D-E)

People with inflammatory disorders like rheumatoid arthritis should know that we don't have enough evidence to confirm if NAD supplements are safe for these conditions [2]