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Wilson's Disease: Facing the Challenge of Diagnosing a Rare Disease

doi: 10.1016/j.neuint.2017.07.014 44 SwidsinskiADrffelYLoening-BauckeVTheissigFRckertJCIsmailMet al

In animal models, subjects treated with SLU-PP-332 were able to run 70% longer and 45% further on treadmill tests compared to controls, despite no increase in actual physical activity

Therapeutic strategies and drug development The clinical translation of PRLMs is constrained by their intrinsic biological properties, which pose marked challenges

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However, cBMAT adipocytes are resistant to conventional lipolytic cues such as acute fasting, caloric restriction, exercise, -adrenergic agonists and cold exposure 2,3,5,6,7,11,12,13