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Higher mitochondrial activity in GSCs would result to an increase in ROS concentrations

Among phenols, resveratrol, a nonflavonoid phenol, is produced in some plants (grapes) in response to bacterial or fungal infection and has an antioxidant effect

In contrast, Sprague-Dawley rats fed diets containing technical-grade dimethipin for two years showed increased incidences and severity of seminiferous tubular degeneration at the two highest doses, 1750 and 3500 ppm (equal to 78 and 160 mg/kg bw per day), associated at the high dose with hypospermia in the epididymides

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doi: 10.1016/j.expneurol.2022.114237