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Activation of microglia and astrocytes, along with increased central cytokine signaling, has been reported across mood episodes and may contribute to synaptic dysfunction and mood instability

In addition, increasing dietary Tryptophan intake or using AHR agonists can reverse neurodeficiencies associated with dysbiosis, especially in AD models, where IPA exerts neuroprotective effects through the CPR30/AMPK/SIRT1 pathway and has antioxidant effects (Rakshe et al., 2024)

Mitochondrial deacetylase Sirt3 reduces vascular dysfunction and hypertension while Sirt3 depletion in essential hypertension is linked to vascular inflammation and oxidative stress

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, 216 , 303-308, Khrle, J