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Among the PEX proteins, PEX5 closely regulates pexophagy

Knockout of Krppel-like factor 14 (KLF14) and Krppel-like factor 15 (KLF15) in renal tubular cells, as well as activation of activating transcription factor 6 (ATF6) overexpression, can inhibit PPAR, reduce FAO mitochondrial activity, lead to lipid accumulation and insufficient energy supply in renal tubular cells, increase apoptosis, and ultimately cause lipotoxicity-induced RF [45,46,47]

MiRNA downregulation was mainly due to the hypermethylation of the CpG island in the promoter region of these miRNAs

This antioxidant and its associated enzymes can efficiently bind a wide range of toxins , including reactive oxygen species, peroxides, lipid peroxides, and heavy metals