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Week 1-4: 1mg weekly Week 5-8: 2mg weekly Week 9-12: 4mg weekly Week 13-16: 6mg weekly Week 17-20: 8mg weekly Week 21+: 12mg weekly (if tolerated) The Phase 3 TRIUMPH-4 trial used a slightly modified approach

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doi: 10.1158/1535-7163.Mct-13-0870 116 HuangFZhangQMaHLvQZhangT

The formation of the NLRP3 inflammasome is triggered by both internal and external factors, such as pathogen-associated molecular patterns (PAMPs), danger/damage-associated molecular patterns (DAMPs), and ROS (121, 123)

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Abstract This chapter presents a basic overview of the clinical pharmacology and mechanism of action of disulfiram