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Pathol Int 65:210219 Kansanen E, Kuosmanen SM, Leinonen H, Levonen A-L (2013) The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer

5C) were predicted in JASPAR 20 in sequences upstream of the ACAT2 transcription start site (chr6: 159761045-159762044)

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Instead of degrading cystathionine via cystathionine--lyase, as in the biosynthetic pathway, cystathionine is broken down to cysteine and -ketobutyrate via (6) cystathionine--lyase

The depletion of this antioxidant has been correlated with lower immune function and increased vulnerability to infection due to the liver's reduced ability to detoxify

Human INMT was expressed in the lung, thyroid, adrenal gland, heart, and muscle but not in the brain (Thompson et al., 1999)