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This alkaline environment favors the overgrowth of microorganisms capable of utilizing urea as an energy source while suppressing saccharolytic bacteria that produce short-chain fatty acids (SCFAs) (101)

Since nitrous oxide is commonly used for surgery in the elderly, some experts feel vitamin B 12 deficiency should be ruled out prior to its use or prophylactic vitamin B 12 supplementation implemented before and after exposure to the gas (7, 18)