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This might be considered unexpected because these neighboring structures are central to two of the three cytokine-to-brain pathways described in section Inflammation neurocircuitry : the NTS is where vagus nerve enters the brainstem, and area postrema is a key circumventricular organ

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Blood-brain barrier disruption in humans using an implantable ultrasound device: quantification with MR images and correlation with local acoustic pressure

2014;40 doi: 10.1111/apt.12878

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They are often broken down by stomach acid before they can reach the small intestine