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Figure 6 3.8 CB-839 did not improve cytotoxicity in combination with venetoclax, AZD-5991, and ibrutinib in primary CLL lymphocytes We then tested these drug combinations in the primary CLL cells, both in the native condition ( Figure 7A ) and in media supplemented with cytokines (CD40 ligand and interleukin-4) to mimic the microenvironment and maintain viability ( Figure 7B )

Orsola-Malpighi Hospital, (11)Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli, (12)Division of Gastroenterology and Hepatology, Foundation Irccs Ca Granda Ospedale Maggiore Policlinico, Milan, Italy, (13)CRC "a

Our previous study also identified a significant association between the NNMT genetic variant at rs1941404 and T2D in the Chinese Han population (Li et al., 2018)

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