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Anesthesia & Analgesia, 92(5), 1319-1321

during the pyroptosis process, GSDMD-NT rapidly damages both IMM and OMM leading to reduced mitochondrial numbers, mitophagy, ROS, loss of transmembrane potential, attenuated oxidative phosphorylation and release of mitochondrial proteins and DNA from the matrix and intermembrane space (136)

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CamposMGWebbyRFMarkhamKRMitchellKADa CunhaAP

In those preclinical models, BPC-157 has been associated with effects on angiogenesis, on growth-factor expression including VEGF and FGF, and on the nitric oxide system

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