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1996) Two thiyl radicals can combine and form a non-radical oxidized glutathione (GSSG) The GSH/GSSG ratio is a good marker of oxidative stress of an organism (Hwang et al

Amyotrophic lateral sclerosis The molecular mechanism of excitotoxicity in ALS involves the excessive release of glutamate, causing Ca 2+ overload and excessive activation of the glutamate receptor AMPA, thereby inducing astrocyte proliferation, mitochondrial dysfunction, and energy exhaustion